Table 1.

Effect of β-BA on carrageenan-induced pleurisy in rats

Treatment	Exudate volume (mL)	Inflammatory cells × 106	PGE2 (ng·rat−1)
Vehicle	0.19 ± 0.020	47.1 ± 3.0	2.15 ± 0.20
β-BA	0.029 ± 0.016***	29.6 ± 2.8***	1.21 ± 0.14**
1 mg·kg−1	85%	37%	44%
Indo	0	17.0 ± 4.9**	n.d.
5 mg·kg−1	100%	64%	100%

^**P < 0.01;

^***P < 0.001 versus vehicle.

Thirty minutes before intrapleural injection of carrageenan, rats (n = 11 for each experimental group) were treated per os with 1 mg·kg⁻¹β-BA, 5 mg·kg⁻¹ indomethacin (indo) or vehicle (water containing 0.5% CMC, 10% Tween-20 and 1% sesame oil). Exudate volume and PGE₂, as well as inflammatory cell accumulation in the pleural cavity were assessed 4 h after carrageenan injection. Data are expressed as mean ± SEM, n = 11.

β-BA, β-boswellic acid; n.d., not detectable, under the limit of detection of the assay (0.0625 ng·mL⁻¹).