Figure 2.
Cannabidiol (CBD)-mediated decrease in action potential (AP) firing frequency in hippocampal cultures is sensitive to the cannabinoid receptor inverse agonist, LY320135. (A) Representative traces illustrating the depolarization and consequent elimination of spontaneous APs observed following the application of AM251 (30 nM). (B) Representative traces showing the reduction in AP firing in the presence of the 5-HT1A agonist, 8-OH-DPAT. (C) Summary data showing the effect of LY320135 and WAY100135 on CBD and 8-OH-DPAT-mediated inhibition of AP firing. **P < 0.01, # P < 0.05 compared with CBD or 8-OH-DPAT alone.