Table 3.
Cox regression analysis showing genetic variants with p-values <0.10 (ascending order).
| Gene | SNP | Chr | Position | MAF | HR | 95%CI lower | upper | puncorrected |
|---|---|---|---|---|---|---|---|---|
| TotCVD | ||||||||
| TEP1 | rs8017603 | 14 | 19973745 | 0.4951 | 0.889583 | 0.818307 | 0.967067 | 0.006 |
| TEP1 | rs1713434 | 14 | 19951366 | 0.4386 | 0.891394 | 0.817883 | 0.971511 | 0.0088 |
| TNKS | rs6601328 | 8 | 9440612 | 0.1096 | 1.174958 | 1.03447 | 1.334525 | 0.013 |
| TEP1 | rs7140768 | 14 | 19966696 | 0.4287 | 1.110475 | 1.021539 | 1.207154 | 0.014 |
| TEP1 | rs7145318 | 14 | 19966903 | 0.4283 | 1.110155 | 1.021259 | 1.206788 | 0.014 |
| ACD | rs9972635 | 16 | 66240080 | 0.05534 | 0.774298 | 0.631705 | 0.949079 | 0.014 |
| TEP1 | rs1878705 | 14 | 19975354 | 0.3784 | 0.911662 | 0.835735 | 0.994486 | 0.037 |
| TNKS | rs11994018 | 8 | 9531110 | 0.1202 | 1.12395 | 0.992396 | 1.272942 | 0.066 |
| UCP2 | rs622064 | 11 | 73350221 | 0.2215 | 0.910262 | 0.819365 | 1.011244 | 0.080 |
| TERT | rs35033501 | 5 | 1306917 | 0.02486 | 1.242142 | 0.968353 | 1.593339 | 0.088 |
| TEP1 | rs1760897 | 14 | 19946092 | 0.3146 | 0.924773 | 0.844075 | 1.013187 | 0.093 |
| MI | ||||||||
| TEP1 | rs1760898 | 14 | 19942720 | 0.2245 | 0.770398 | 0.622786 | 0.952996 | 0.016 |
| TEP1 | rs8022805 | 14 | 19916789 | 0.05567 | 0.572957 | 0.361111 | 0.909082 | 0.018 |
| TERT | rs4975605 | 5 | 1328527 | 0.4696 | 1.215978 | 1.033112 | 1.431212 | 0.019 |
| TERT | rs33961405 | 5 | 1330576 | 0.4877 | 0.822649 | 0.698133 | 0.969374 | 0.020 |
| TEP1 | rs1760897 | 14 | 19946092 | 0.3146 | 0.808691 | 0.673295 | 0.971313 | 0.023 |
| ACD | rs9972635 | 16 | 66240080 | 0.05626 | 0.600607 | 0.385511 | 0.935716 | 0.024 |
| TERT | rs34363858 | 5 | 1339476 | 0.01613 | 0.203405 | 0.050638 | 0.817037 | 0.025 |
| TERT | rs2736100 | 5 | 1339515 | 0.4967 | 1.199794 | 1.021203 | 1.409618 | 0.027 |
| TEP1 | rs2228041 | 14 | 19922106 | 0.0578 | 0.611007 | 0.393707 | 0.948242 | 0.028 |
| ACD | rs9972635 | 16 | 66240080 | 0.05534 | 0.609396 | 0.39127 | 0.949125 | 0.028 |
| TERT | rs7447815 | 5 | 1293756 | 0.3938 | 1.196905 | 1.015123 | 1.411241 | 0.032 |
| TEP1 | rs3093926 | 14 | 19892891 | 0.06307 | 0.669189 | 0.447248 | 1.001267 | 0.051 |
| TNKS | rs11787063 | 8 | 9483709 | 0.2666 | 0.826178 | 0.68119 | 1.002025 | 0.052 |
| TERF2 | rs715162 | 16 | 67927758 | 0.05932 | 0.683803 | 0.461551 | 1.013077 | 0.058 |
| TERF2 | rs7187579 | 16 | 67942359 | 0.1803 | 1.21057 | 0.989883 | 1.480459 | 0.063 |
| TERT | rs33954691 | 5 | 1308519 | 0.1029 | 1.232049 | 0.9632 | 1.575941 | 0.097 |
| IsStroke | ||||||||
| TERF2IP | rs3784929 | 16 | 74234527 | 0.1139 | 1.379248 | 1.73083 | 1.099083 | 0.006 |
| TNKS2 | rs10881985 | 10 | 93617137 | 0.3035 | 1.246918 | 1.473113 | 1.055456 | 0.010 |
| TNKS2 | rs2066275 | 10 | 93554294 | 0.3036 | 1.245483 | 1.471446 | 1.054219 | 0.010 |
| TNKS | rs9644704 | 8 | 9597578 | 0.3628 | 1.237947 | 1.456212 | 1.052396 | 0.010 |
| TNKS | rs7015700 | 8 | 9565116 | 0.1802 | 1.286949 | 1.561474 | 1.060689 | 0.010 |
| TERF2IP | rs8053257 | 16 | 74232188 | 0.0604 | 1.464099 | 1.962009 | 1.092546 | 0.011 |
| TNKS | rs6994574 | 8 | 9615664 | 0.3651 | 1.233861 | 1.451365 | 1.048952 | 0.011 |
| TNKS | rs12155819 | 8 | 9610088 | 0.3641 | 1.22941 | 1.445951 | 1.045298 | 0.012 |
| TEP1 | rs2228041 | 14 | 19922106 | 0.0578 | 1.457458 | 1.969814 | 1.078367 | 0.014 |
| UCP2 | rs622064 | 11 | 73350221 | 0.2215 | 0.776632 | 0.959502 | 0.628615 | 0.019 |
| TNKS | rs11994018 | 8 | 9531110 | 0.1202 | 1.304788 | 1.634687 | 1.041467 | 0.021 |
| TNKS | rs6601328 | 8 | 9440612 | 0.1096 | 1.307125 | 1.651757 | 1.0344 | 0.025 |
| TERT | rs35033501 | 5 | 1306917 | 0.02486 | 1.613968 | 2.454539 | 1.061256 | 0.025 |
| TEP1 | rs2184282 | 14 | 19949999 | 0.1279 | 1.278122 | 1.590322 | 1.02721 | 0.028 |
| TEP1 | rs2104978 | 14 | 19906872 | 0.06524 | 1.380391 | 1.843774 | 1.033466 | 0.029 |
| TEP1 | rs8022805 | 14 | 19916789 | 0.05567 | 1.409067 | 1.920826 | 1.033654 | 0.030 |
| TNKS | rs4841218 | 8 | 9691311 | 0.3732 | 1.196219 | 1.406731 | 1.017209 | 0.030 |
| TEP1 | rs1713456 | 14 | 19919932 | 0.1813 | 1.236704 | 1.503069 | 1.017543 | 0.033 |
| TERT | rs2853668 | 5 | 1353024 | 0.2526 | 0.80919 | 0.98382 | 0.665557 | 0.034 |
| TNKS2 | rs1361552 | 10 | 93524603 | 0.4259 | 1.190833 | 1.400015 | 1.012906 | 0.034 |
| TEP1 | rs1713456 | 14 | 19919932 | 0.1812 | 1.230731 | 1.496781 | 1.01197 | 0.038 |
| TEP1 | rs1713434 | 14 | 19951366 | 0.4386 | 0.843648 | 0.996433 | 0.71429 | 0.045 |
| TNKS | rs6601327 | 8 | 9432941 | 0.3785 | 1.180241 | 1.388515 | 1.003208 | 0.046 |
| TEP1 | rs7145318 | 14 | 19966903 | 0.4283 | 1.173779 | 1.377184 | 1.000417 | 0.049 |
| TEP1 | rs7140768 | 14 | 19966696 | 0.4287 | 1.166236 | 1.368283 | 0.994024 | 0.059 |
| TNKS | rs6985140 | 8 | 9574836 | 0.07697 | 1.299513 | 1.709239 | 0.988004 | 0.061 |
| TNKS2 | rs2258946 | 10 | 93614651 | 0.1487 | 0.797235 | 1.019431 | 0.623469 | 0.071 |
| TERT | rs34363858 | 5 | 1339476 | 0.01613 | 1.580129 | 2.652757 | 0.941212 | 0.083 |
| ACD | rs7187476 | 16 | 66257448 | 0.1548 | 1.208285 | 1.500459 | 0.973004 | 0.087 |
| TNKS | rs12545912 | 8 | 9639108 | 0.2488 | 1.169519 | 1.399183 | 0.977553 | 0.087 |
| TEP1 | rs3093926 | 14 | 19892891 | 0.06557 | 1.293974 | 1.738674 | 0.963015 | 0.087 |
| TERF1 | rs6994351 | 8 | 74069183 | 0.3952 | 0.863512 | 1.023128 | 0.728797 | 0.090 |
| UCP2 | rs1626521 | 11 | 73391986 | 0.274 | 0.851841 | 1.029147 | 0.705082 | 0.096 |
Adjusted for age, BMI, current smoking, treatment assignment, history of diabetes, hypertension and hyperlipidemia, and current hormone use.
MAF=minor allele frequency; Chr.=chromosome; HR=hazard ratio.