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. Author manuscript; available in PMC: 2011 Mar 1.
Published in final edited form as: Cancer Res. 2010 Aug 24;70(17):6715–6724. doi: 10.1158/0008-5472.CAN-10-1377

Figure 4. Feedback loops in the ERK and Wnt signaling pathways have different roles in the regulation of E-cadherin.

Figure 4

(A) The positive feedback loop (including F4F5) significantly increases SD where the activity of PKCδ gets increased through inhibition of GSK3β by ERK phosphorylation. (B) The positive feedback loop (including F2) mediated by RKIP significantly increases STI. (C) EC50 is significantly decreased by CFLs (including F2F3) formed by the positive feedback mediated by RKIP and the negative feedback by ERK mediated phosphorylation of the SOS/Grb2 complex.

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