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. Author manuscript; available in PMC: 2012 Mar 1.
Published in final edited form as: Cell Signal. 2010 Nov 29;23(3):594–601. doi: 10.1016/j.cellsig.2010.11.013

Fig. 5.

Fig. 5

5FOA growth response to exogenous cAMP and cGMP in strains lacking the S. pombe Cgs2 PDE or expressing mammalian PDE5A or PDE9A genes. 5FOA growth was measured as in Fig. 1 in strains expressing mammalian cGMP-specific PDE5A or PDE9A genes in response to varying concentrations of exogenous cAMP or exogenous cGMP. A) Growth response at low concentrations of cyclic nucleotides. B) Growth response through the full range of cyclic nucleotide addition. Values represent the average OD600 from four replicate wells after 48hr growth at 30°C.