Fig. 2.

Structural comparison between EBV gH/gL, HSV gH/gL, and PRV gH. (A) EBV gH/gL was superimposed with the structures of HSV-2 gH/gL (28) and a three-domain fragment of PRV gH through D-II. The EBV structure is shown in dark blue, the HSV-2 structure is in yellow (33), and the PRV structure is in light red, with the EBV gH/gL domain boundaries indicated by labels. (B) A schematic representation of the EBV gH/gL structure is shown colored as in Fig. 1B and with the domains indicated. Interdomain packing changes between the structures are indicated, with approximated rotations given for the largest changes observed between the EBV and HSV-2 structures at the D-I/D-II and D-II/D-III interfaces. (C) Superposition of the EBV and HSV-2 structures through D-I residues. (D) Schematic representation of the EBV and HSV-2 D-I superposition showing the reorientation of the gH domains. (E) Superposition of the EBV and HSV-2 structures through D-III residues. (F) Schematic representation of the EBV and HSV-2 D-III superposition showing the reorientation of the N-terminal D-II and D-I domains. Although individual domains consist of similar core structures, the changes in interdomain packing create different overall shapes, especially for the EBV and HSV-2 structures.