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. 2010 Dec 13;107(52):22687–22692. doi: 10.1073/pnas.1012851108

Fig. 3.

Fig. 3.

CBP gene transfer rescues learning and memory deficits in 3xTg-AD mice. CBP-expressing lentiviruses were injected into the dorsolateral ventricles of 3xTg-AD mice (n = 18) and NonTg mice (n = 17). In addition, 17 3xTg-AD mice and 16 NonTg mice received sham injections. Six mice per group were sacrificed after 3 d and 5 d of training. (A) All mice were evaluated in the spatial reference version of the MWM. The escape latency was significantly lower in the CBP-injected 3xTg-AD mice than in the sham-injected 3xTg-AD mice (P = 0.008). (B–D) Reference memory was significantly improved in the CBP-injected 3xTg-AD mice compared with the sham-injected 3xTg-AD mice in all probe trial measurements conducted. Data are presented as mean ± SEM. *P < 0.05.