Skip to main content
. 2010 Dec 13;107(52):22687–22692. doi: 10.1073/pnas.1012851108

Fig. 5.

Fig. 5.

CBP gene delivery rescues BDNF levels. (A) Representative Western blots of proteins extracted from the hippocampi of CBP- and sham-injected 3xTg-AD and NonTg mice and probed with an anti-BDNF antibody. (B) Quantitative analysis of the blots shows that in the hippocampi of the 3xTg-AD mice, CBP gene delivery restored the levels of pro-BDNF and BDNF to NonTg levels. (C) Representative Western blots of proteins extracted from the hippocampi of 6-mo-old sham- and CBP-injected 3xTg-AD and NonTg mice (n = 6/genotype) after 5 d of training and probed with the indicated antibodies. (D–F) Quantitative analysis of the blots shows that after 5 d of training, the pNR2B, PKA, and pERK levels were significantly increased in the CBP-injected 3xTg-AD mice compared with sham-injected 3xTg-AD mice. In contrast, no differences were found between the sham- and CBP-injected NonTg mice. Data are presented as fold changes over sham-injected NonTg mice and represent mean ± SEM. *P < 0.05.