Fig. 5.
Response of TC-RE pair to cortical drive. (A) TC-RE model cell spiking at the baseline (gGABA = 0.04). Spiking is sparse and uncorrelated. (B) TC-RE model cell spiking at a high-dose level (gGABA = 0.14). Spiking is entrained to the 12-Hz drive (the drive arrives at the dashed vertical lines). (C) Detail of activity from 4,160–4,260 ms. (Top to Bottom) RE voltage, TC voltage, gh (in TC cell), and IGABA (in TC cell) for baseline (thin line) and propofol (thick line) conditions. The increased IGABA and, consequently, the Ih are important in promoting the rhythmic thalamic response. (D) Mean Synchronization (Sync) Index obtained over different noise realizations for the single TC-RE pair with a 12-Hz cortical drive (n = 20). As GABA increases beyond twofold the baseline value, the SI increases, reflecting entrainment of the thalamic cells to the cortical excitation.