Figure 7.
Aluminum adjuvant fibrin ETs are not required for adaptive immunity. C57BL/6, FibA Het, or FibA KO mice were vaccinated with 3K-OVA plus aluminum adjuvant. (A) Nine days later, the number of 3K-specific CD4 T cells and SIINFEKL-specific CD8 T cells per spleen were determined with IAb-3K and Kb-SIINFEKL tetramers, respectively (*P = .03). (B) Also at day 9, serum OVA-specific IgG1 and IgG2c antibodies were measured by ELISA. Small diamonds indicate individual mice and large circles indicate the geometric mean. Data are pooled from 3 experiments, n = 6-10 mice per nonadjuvant group and 8-13 mice per adjuvant group, n.d. indicates not determined.