Table 2.

Clinical GVHD staging strategy

Stage	Skin	Liver (bilirubin)	Gastrointestinal tract	Activity (inversely related to GVHD)
0	No GVHD rash	< 4-fold increase over baseline	No diarrhea	Animal unable to respond normally to stimulation
1	Rash < 25% body surface area	4- to 8-fold increase over baseline	“Mild” diarrhea with no other cause	Severely decreased or altered activity
2	Rash 25%-50% body surface area	8- to 20-fold increase over baseline	“Moderate” diarrhea with no other cause	Moderately decreased or altered activity
3	Rash > 50% body surface area	20- to 50-fold increase over baseline	“Severe” diarrhea with no other cause	Normal activity
4	Generalized erythroderma with bullous formation	> 50-fold increase over baseline	“Very severe” diarrhea with no other cause

GVHD indicates graft-versus-host disease.