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. 2010 Aug 26;116(23):5010–5020. doi: 10.1182/blood-2010-06-290643

Figure 3.

Figure 3

Time course of ATL146e effects in NY1DD mice. NY1DD mice were treated with osmotic minipumps infusing vehicle (■) or ATL146e (10 ng/kg/minute, osmotic pump, ▾). Pulmonary parameters were measured in NY1DD mice treated for 0, 1, 2, 3, or 7 days after the start of infusion. All parameters were maximally improved by 3 days after the start of ATL146e treatment, because no further changes were noted on day 7. The solid and dashed lines represent the mean ± SEM of parameters from congenic C57BL/6 mice. Data were analyzed by 1-way ANOVA with Neuman-Keuls posttesting. *P < .05 vs day 0.