Table 3.
The effects of ATL146e and anti-CD1d on pulmonary leukocyte numbers are not additive
Cells (105) | (a) NY1DD (n = 17) | (b) NY1DD ATL146e (n = 8) | (c) NY1DD anti-CD1d (n = 10) | (d) NY1DD ATL146e anti-CD1d (n = 4) |
---|---|---|---|---|
iNKT | 0.43 (0.03) | 0.30 (0.03)* | 0.20 (0.05)* | 0.16 (0.05)** |
NK | 4.45 (0.77) | 1.21 (0.30)* | 1.51 (0.22)* | 0.90 (0.08)** |
CD4 | 3.12 (0.37) | 1.00 (0.20)* | 1.04 (0.21)* | 1.20 (0.30)** |
CD8 | 2.33 (0.32) | 1.00 (0.15)* | 0.66 (0.18)* | 0.73 (0.23)** |
PMNs | 2.14 (0.31) | 0.38 (0.09)* | 0.84 (0.12)* | 0.52 (0.13)** |
NY1DD mice were treated with either ATL146e (10 ng/kg/minute, 3 days), anti-CD1d (10 μg/g/day, 2 days), or a combination of both. All treatments resulted in significantly decreased pulmonary leukocytes. Data represents the mean ± SEM. Data were analyzed by 1-way ANOVA with Neuman-Keuls posttesting.
P < .05 vs a.
P < .05 vs a, not significantly different from b or c.