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. 2010 Aug 26;116(23):5010–5020. doi: 10.1182/blood-2010-06-290643

Table 3.

The effects of ATL146e and anti-CD1d on pulmonary leukocyte numbers are not additive

Cells (105) (a) NY1DD (n = 17) (b) NY1DD ATL146e (n = 8) (c) NY1DD anti-CD1d (n = 10) (d) NY1DD ATL146e anti-CD1d (n = 4)
iNKT 0.43 (0.03) 0.30 (0.03)* 0.20 (0.05)* 0.16 (0.05)**
NK 4.45 (0.77) 1.21 (0.30)* 1.51 (0.22)* 0.90 (0.08)**
CD4 3.12 (0.37) 1.00 (0.20)* 1.04 (0.21)* 1.20 (0.30)**
CD8 2.33 (0.32) 1.00 (0.15)* 0.66 (0.18)* 0.73 (0.23)**
PMNs 2.14 (0.31) 0.38 (0.09)* 0.84 (0.12)* 0.52 (0.13)**

NY1DD mice were treated with either ATL146e (10 ng/kg/minute, 3 days), anti-CD1d (10 μg/g/day, 2 days), or a combination of both. All treatments resulted in significantly decreased pulmonary leukocytes. Data represents the mean ± SEM. Data were analyzed by 1-way ANOVA with Neuman-Keuls posttesting.

*

P < .05 vs a.

**

P < .05 vs a, not significantly different from b or c.