Table 2. Genes detected by microarray screening as exhibiting significant changes in expression level following treatment of murine retinal progenitor cells (RPCs) with glial cell line-derived neurotrophic factor (GDNF).

Gene symbol*	Gene accession	Gene description	GO_Biological_Process_Term	log2 (fold change)§	-log10 (p-value)#
Olfr988	NM_001011534	olfactory receptor 988	signal transduction;G-protein coupled receptor protein signaling pathway; sensory perception of smell	2.6	1.32
Olfr444	NM_146656	olfactory receptor 444	signal transduction;G-protein coupled receptor protein signaling pathway; sensory perception of smell	−2.39	1.62
Tex12	NM_025687	testis expressed gene 12	—	2.04	1.33
Dnahc7a	XM_001473948	dynein, axonemal, heavy chain 7A	biological_process	1.73	1.63
Olfr1290	NM_146262	olfactory receptor 1290	signal transduction ;G-protein coupled receptor protein signaling pathway; sensory perception of smell	−1.45	1.58
Olfr860	NM_146528	olfactory receptor 860	signal transduction;G-protein coupled receptor protein signaling pathway; sensory perception of smell	−1.43	1.92
Ear1	NM_007894	eosinophil-associated, RNase A family, member 1	—	−1.22	1.56
Olfr486	NM_146496	olfactory receptor 486	signal transduction;G-protein coupled receptor protein signaling pathway; sensory perception of smell; response to stimulus	1.19	1.63
BC021785	ENSMUST00000095749	cDNA sequence BC021785	carbohydrate transport	1.18	2.19
Vmn2r23	NM_001104638	vomeronasal 2, receptor 23	—	1.16	1.94
H2-M10.5	NM_177637	histocompatibility 2, M region locus 10.5	—	1.16	1.52
Olfr1221	NM_146902	olfactory receptor 1221	signal transduction;G-protein coupled receptor protein signaling pathway; sensory perception of smell	1.15	1.34
Dsg1b	NM_181682	desmoglein 1 beta	cell adhesion;homophilic cell adhesion	1.13	2.17
Mafg	AK047224	v-maf musculoaponeurotic fibrosarcoma oncogene family, protein G (avian)	in utero embryonic development; transcription; regulation of transcription, DNA-dependent;adult behavior;regulation of cell proliferation;regulation of epidermal cell differentiation	−1.11	2.02
Fcrls	NM_030707	Fc receptor-like S, scavenger receptor	—	1.02	3.79
Myo9a	ENSMUST00000085572	myosin IXa	—	−1	1.47

A combination of p-value<0.05 [equals that –log₁₀(p-value)>1.3] and absolute value of fold change≥2 [equals the absolute value of log₂(fold change)≥1] were applied. Totally 24 genes were detected and eight of them are predicted genes for which no biologic functions are known so far (data not shown). *: Gene symbol (Gene name; Affymetrix probe set identification) §: log₂(fold change), “#”: “minus values represent the genes that were down regulated in epidermal growth factor (EGF)+ Glial cell line-derived neurotrophic factor (GDNF) compare EGF. Condition of GDNF #: -log₁₀(p-value), p-value, log₁₀ transformed.