Table 3. Haplotype analysis for NOD2 SNPs in the CD patient cohort.
NOD2 haplotypes | p-value | OR | CI lower | CI upper |
rs2066843-rs2066844 | 1.31×10−8 | |||
TT | 1.34×10−5 | 1.94 | 1.81 | 2.08 |
TC | 3.09×10−4 | 1.34 | 1.28 | 1.40 |
CC | 1.72×10−8 | 0.65 | 0.63 | 0.66 |
rs2066844-rs2066845 | 7.94×10−8 | |||
CC | 3.25×10−3 | 1.80 | 1.58 | 2.06 |
TG | 3.80×10−6 | 1.89 | 1.78 | 2.00 |
CG | 1.08×10−8 | 0.52 | 0.50 | 0.54 |
rs2066845-rs2066847 | 1.09×10−18 | |||
GC | 6.88×10−17 | 4.06 | 3.90 | 4.22 |
CX | 6.67×10−3 | 1.74 | 1.50 | 2.02 |
GX | 4.38×10−20 | 0.32 | 0.31 | 0.33 |
rs2066847-rs2076756 | 2.48×10−15 | |||
CG | 2.88×10−14 | 3.84 | 3.67 | 4.02 |
XG | 3.31×10−1 | 1.09 | 0.91 | 1.30 |
XA | 2.35×10−9 | 0.62 | 0.61 | 0.64 |
rs2066843-rs2066844-rs2066845 | 5.94×10−10 | |||
TCC | 1.16×10−3 | 1.90 | 1.69 | 2.14 |
TTG | 8.40×10−7 | 2.01 | 1.90 | 2.13 |
TCG | 2.64×10−2 | 1.21 | 1.12 | 1.31 |
CCG | 9.68×10−10 | 0.62 | 0.61 | 0.64 |
rs2066844-rs2066845-rs2066847 | 8.22×10−24 | |||
CGC | 5.84×10−17 | 4.07 | 3.91 | 4.23 |
CCX | 1.08×10−2 | 1.70 | 1.45 | 1.99 |
TGX | 3.59×10−6 | 1.89 | 1.78 | 2.00 |
CGX | 4.19×10−26 | 0.37 | 0.36 | 0.37 |
rs2066845-rs2066847-rs2076756 | 2.48×10−15 | |||
GCG | 5.41×10−17 | 4.09 | 3.93 | 4.25 |
CXG | 1.04×10−3 | 1.94 | 1.72 | 2.19 |
GXG | 3.47×10−1 | 0.92 | 0.76 | 1.11 |
GXA | 3.89×10−12 | 0.59 | 0.57 | 0.60 |
rs2066843-rs2066844-rs2066845-rs2066847 | 1.60×10−23 | |||
TCGC | 4.10×10−17 | 4.28 | 4.11 | 4.46 |
TCCX | 1.18×10−3 | 1.90 | 1.69 | 2.14 |
TTGX | 8.51×10−7 | 1.99 | 1.88 | 2.10 |
TCGX | 2.32×10−5 | 0.66 | 0.63 | 0.69 |
CCGX | 8.57×10−13 | 0.59 | 0.58 | 0.60 |
rs2066844-rs2066845-rs2066847-rs2076756 | 1.14×10−23 | |||
CGCG | 5.20×10−17 | 4.04 | 3.89 | 4.20 |
CCXG | 1.10×10−3 | 1.93 | 1.71 | 2.18 |
TGXG | 4.75×10−7 | 2.06 | 1.95 | 2.18 |
CGXG | 1.24×10−5 | 0.642 | 0.61 | 0.67 |
CGXA | 7.82×10−13 | 0.59 | ||
rs2066843-rs2066844-rs2066845-rs2066847-rs2076756 | 1.43×10−21 | |||
TCGCG | 6.33×10−17 | 4.18 | 4.02 | 4.35 |
TCCXG | 1.07×10−3 | 1.93 | 1.71 | 2.18 |
TTGXG | 6.00×10−7 | 2.05 | 1.94 | 2.17 |
TCGXG | 9.42×10−5 | 0.67 | 0.64 | 0.71 |
TCGXA | 6.48×10−2 | 0.576 | 0.42 | 0.79 |
CCGXA | 2.01×10−11 | 0.61 | 0.60 | 0.63 |
Omnibus as well as individual p-values are presented.