Table 4. Association between rs2066843 genotype and CD disease characteristics based on the Montreal classification [28].

rs2066843 genotype status	(1)CCn = 322	(2)CTn = 345	(3)TTn = 150	(1) vs. (2)p-valueOR [95% CI]	(1) vs. (3)p-valueOR [95% CI]	(1) vs. (2) + (3)p-valueOR [95% CI]
Age at diagnosis≤16 years (A1)17–40 years (A2)>40 years (A3)	74/239 (31.0%)150/239 (62.8%)15/239 (6.2%)	81/237 (34.2%)125/237 (52.7%)31/237 (13.1%)	37/116 (31.9%)69/116 (59.5%)10/116 (8.6%)	0.4941.16 (0.79–1.70)0.0330.66 (0.46–0.95)0.0132.25 (1.18–4.28)	0.9031.04 (0.65–1.68)0.5620.87 (0.55–1.37)0.5071.41 (0.61–3.24)	0.5911.12 (0.79–1.59)0.0620.72 (0.52–1.01)0.0321.96 (1.06–3.63)
LocationTerminal ileum (L1)Colon (L2)Ileocolon (L3)Upper GI (L4)Any ileal involvement(L1+L3)	32/244 (13.1%)42/244 (17.2%)166/244 (67.9%)4/244 (1.6%)198/244 (81.1%)	46/238 (19.3%)33/238 (13.9%)155/238 (65.1%)4/238 (1.7%)201/238 (84.5%)	12/120 (10.0%)11/120 (9.2%)93/120 (77.5%)4/120 (3.3%)105/120 (87.5%)	0.0831.59 (0.97–2.59)0.3180.77 (0.47–1.27)0.5010.88 (0.60–1.28)1.0001.03 (0.25–4.15)0.3981.26 (0.78–2.03)	0.4940.74 (0.36–1.49)0.0410.48 (0.24–0.98)0.0661.62 (0.98–2.68)0.4472.07 (0.51–8.42)0.1381.63 (0.87–3.05)	0.3521.28 (0.80–2.04)0.0970.67 (0.43–1.07)0.7881.06 (0.75–1.50)0.7701.37 (0.41–4.61)0.1771.37 (0.88–2.11)
Behaviour 1Non-stricturing,Non-penetrat. (B1)Stricturing (B2)Penetrating (B3)	49/232 (21.1%)66/232 (28.4%)117/232 (50.4%)	61/233 (26.2%)64/233 (27.5%)108/233 (46.3%)	18/116 (15.5%)27/116 (23.3%)71/116 (61.2%)	0.2301.32 (0.86–2.04)0.8370.95 (0.63–1.43)0.4040.85 (0.59–1.22)	0.2490.69 (0.38–1.24)0.3680.76 (0.45–1.28)0.0681.55 (0.98–2.44)	0.6841.09 (0.73–1.63)0.5670.89 (0.61–1.29)0.8661.03 (0.74–1.44)

¹Disease behaviour was defined according to the Montreal classification [28]. Stricturing disease phenotype was defined as presence of stenosis without penetrating disease. The diagnosis of stenosis was made surgically, endoscopically, or radiologically (using MR enteroclysis). For each variable, the number of patients included is given.