Table 5. Association between rs2066843 genotype and CD disease characteristics.
| rs2066843 genotype status | (1)CCn = 322 | (2)CTn = 345 | (3)TTn = 150 | (1) vs. (2)p-valueOR [95% CI] | (1) vs. (3)p-valueOR [95% CI] | (1) vs. (2) + (3)p-valueOR [95% CI] |
| Male sex | 129/277 (46.6%) | 153/289 (52.9%) | 74/134 (55.2%) | 0.1311.29 (0.93–1.80) | 0.1151.41 (0.94–2.14) | 0.0751.33 (0.98–1.80) |
| Age at diagnosis (yrs)Mean ± SDRange | 27.1±10.911–70 | 28.7±12.51–78 | 25.8±11.36–71 | 0.151 | 0.302 | 0.526 |
| Disease duration (yrs)Mean ± SDRange | 12.3±8.40–37 | 11.4±9.011–44 | 11.8±8.21–35 | 0.381 | 0.675 | 0.403 |
| Body mass index (yrs)Mean ± SDRange | 23.3±4.416–40 | 23.4±4.016–37 | 22.0±3.613–31 | 0.845 | 0.039 | 0.473 |
| Use of immunosuppressive agents 2 | 141/169 (83.4%) | 135/175 (77.1%) | 70/83 (84.3%) | 0.1760.67 (0.39–1.15) | 1.0001.07 (0.52–2.19) | 0.3160.77 (0.46–1.27) |
| Surgery because of CD 3 | 113/221 (51.1%) | 120/224 (53.6%) | 76/116 (65.5%) | 0.6361.10 (0.76–1.60) | 0.0151.82 (1.14–2.89) | 0.1401.30 (0.93–1.83) |
| Fistulas | 117/232 (50.4%) | 108/233 (46.3%) | 71/116 (61.2%) | 0.4040.85 (0.59–1.22) | 0.0681.55 (0.98–2.44) | 0.8661.03 (0.74–1.44) |
| Perianal fistulas | 24/92 (26.1%) | 18/90 (20.0%) | 7/49 (14.3%) | 0.2121.41 (0.70–2.83) | 0.0792.12 (0.84–5.34) | 0.0961.61 (0.85–3.04) |
| Stenosis | 140/229 (61.1%) | 144/233 (61.8%) | 80/115 (69.6%) | 0.9241.03 (0.71–1.50) | 0.1531.45 (0.90–2.34) | 0.4811.15 (0.81–1.62) |
2
Immunosuppressive agents included azathioprine, 6-mercaptopurine, 6-thioguanine, methotrexate, and/or infliximab.
3
Only surgery related to CD-specific problems (e.g. fistulectomy, colectomy, ileostomy) was included. For each variable, the number of patients included is given.