Table 6. Association between rs2076756 genotype and CD disease characteristics based on the Montreal classification [28].

rs2076756 genotype status	(1)AAn = 339	(2)AGn = 334	(3)GGn = 143	(1) vs. (2)p-valueOR [95% CI]	(1) vs. (3)p-valueOR [95% CI]	(1) vs. (2) + (3)p-valueOR [95% CI]
Age at diagnosis≤16 years (A1)17–40 years (A2)>40 years (A3)	73/241(30.3%)154/241(63.9%)14/241 (5.8%)	75/233 (32.2%)124/233 (53.2%)34/233 (14.6%)	35/110 (31.8%)66/110 (60.0%)9/110 (8.2%)	0.6921.09 (0.74–1.61)0.0200.64 (0.44–0.93)0.0022.77 (1.44–5.31)	0.8041.07 (0.66–1.75)0.5520.85 (0.53–1.35)0.4861.44 (0.61–3.45)	0.7171.09 (0.76–1.55)0.0410.70 (0.50–0.98)0.0072.32 (1.24–4.35)
LocationTerminal ileum (L1)Colon (L2)Ileocolon (L3)Upper GI (L4)IleocolonicInvolvement	31/245 (12.7%)41/245 (16.7%)169/245 (70.0%)4/245 (1.6%)200/245 (81.6%)	45/235 (19.1%)34/235 (14.5%)152/235 (64.7%)4/235 (1.7%)197/235 (83.8%)	11/113 (9.7%)9/113 (8.0%)89/113 (78.8%)4/113 (3.5%)100/113 (88.5%)	0.0611.63 (0.99–2.69)0.5310.84 (0.51–1.38)0.3330.82 (0.56–1.20)1.0001.04 (0.26–4.22)0.5481.17 (0.73–1.87)	0.4830.74 (0.36–1.54)0.0320.43 (0.20–0.92)0.0581.67 (0.99–2.82)0.2682.21 (0.54–9.00)0.1231.73 (0.89–3.36)	0.2891.32 (0.82–2.12)0.1510.70 (0.44–1.11)1.0001.01 (0.71–1.44)0.7691.48 (0.42–4.76)0.2581.31 (0.84–2.03)
Behaviour 1Non-stricturing,Non-penetrat. (B1)Stricturing (B2)Penetrating (B3)	49/232 (21.1%)67/232 (28.9%)116/232 (50.0%)	64/231 (27.7%961/231 (26.4%)106/231 (45.9%)	12/109 (11.0%)27/109 (24.8%)70/109 (64.2%)	0.1061.43 (0.93–2.19)0.6040.88 (0.59–1.33)0.4030.85 (0.59–1.22)	0.0230.46 (0.23–0.91)0.5160.81 (0.48–1.36)0.0151.79 (1.12–2.87)	0.7581.07 (0.72–1.61)0.4440.86 (0.59–1.25)0.7331.07 (0.77–1.50)