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. 2010 Dec 30;5(12):e15852. doi: 10.1371/journal.pone.0015852

Figure 1. hMena is differently distributed among breast cancer subtypes and correlates with HER2 overexpression, MAPK, AKT activity and Ki67.

Figure 1

A. Relationship between hMena staining and HER2 positivity in human breast carcinomas. Histograms represent the percentage of the hMena staining (score 0; 1; 2; 3) in 82 HER2 positive breast cancer samples (2+ with gene amplification and 3+) (p = 0.02). B. hMena distribution within 286 human breast carcinomas grouped according to molecular subtypes. hMena expression (0, 1, 2, 3 scores) in Luminal A, Luminal B, HER2 subtypes and Triple Negative. The percentage of hMena-positive cases (score 3) is significantly higher in the HER2 subtype and Triple-Negative in comparison to Luminal A and Luminal B breast cancer (p = 0.032). C. Correlation between hMena expression and HER2, P-AKT, P-MAPK and Ki67 in a subgroup of 178 breast cancer patients. Percentage of HER2 positivity, high Ki67 proliferation index, elevated P-AKT and P-MAPK expression for each hMena score. The percentage of HER2 positivity (p = 0.016), P-AKT (p<0.001) and P-MAPK (p<0.001) overexpression, high Ki67 proliferation index (p = 0.016) increase significantly in relationship to hMena score (0 to 1 to 2 to 3). D. Representative case of an invasive ductal carcinoma with a strong hMena positivity (score 3+) displaying HER2 overexpression (score 3 by IHC), P-MAPK and P-AKT positivity, elevated Ki67 index. Magnification, 40x. Original scale 1 cm = 30micron (25 cm×33 cm).