Skip to main content
. Author manuscript; available in PMC: 2011 Jul 1.
Published in final edited form as: Mucosal Immunol. 2010 Sep 15;4(1):102–111. doi: 10.1038/mi.2010.57

Figure 8. Salmonella flagellin and TLR5 interaction is required for in vivo sIL-1Ra secretion.

Figure 8

(A) Eight week old BALB/CJ mice were pretreated with streptomycin and 24 h later infected orally with flagellate S. Typhimurium or its aflagellate isogenic mutant. After 48 h post infection, mice were bled and serum analysed by ELISA for sIL-1Ra levels. (B) Eight week old wild-type (WT), TLR5KO (T5KO), IPAFKO and IPAF/TLR5 DKO mice were orally infected with flagellate S. Typhimurium or its aflagellate isogenic mutant (1×108 CFU/mouse). Twelve hour post infection, mice were bled and serum sIL-1Ra quantified by ELISA. The results are representative of two independent experiments. * p<0.05