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. Author manuscript; available in PMC: 2012 Mar 1.
Published in final edited form as: J Cell Physiol. 2011 Mar;226(3):785–791. doi: 10.1002/jcp.22399

Figure 6.

Figure 6

Model of Mybl2's role in coordinating expression of cell cycle regulatory genes to prime cells for commitment to lineage-specific differentiation. In proliferating cells, Mybl2 may cause cells to pause in G1 long enough to receive and process differentiation induction signals by modestly activating expression of genes, such as cyclin B2 and cdc25B, that promote progression through G2/M and suppressing expression of genes, including cdk2, cyclin D2, and c-myc, that drive progression through G1. Once cells are induced to differentiate, Mybl2 is downregulated, and other factors completely arrest cells in G1 and robustly activate maturation-specific gene expression.