Table 3.

Summary of the potential pro and anti-athero-thrombosis and AAA roles that the angpts play.

Angpts	Pro-athero-thrombosis and AAA	Anti-athero-thrombosis and AAA
Inflammation
Angpt 2	Chemoattractant for Tie-2 monocytes [55]. Angpt 2−/− mice showed an inability to mount an inflammatory response, a phenotype that was rescued upon rAngpt 2 administration [54]. The same affect was seen when sTie-2 was administered to mice. Facilitates the translocation of adhesion molecules in ECs [47]. Activate ECs and neutrophils [59].
Angpt 1	Activate ECs and neutrophils [59].	Reduces VEGF induction of adhesion molecules on ECs [82,83].
Angiogenesis
Angpt 2	Increases angiogenesis when co-expressed with VEGF [17].