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Calcium-induced high-amplitude swelling (t1/2) in aging Sod2tm1Cje (+/−) and (+/+) mouse livers. The opening of the mtPTP was measured by cyclosporin A-inhibitable high-amplitude swelling in Sod2tm1Cje (+/−) (▴) and controls (●). The t1/2 is defined as the time in seconds until the mitochondria are half maximally swollen. The data shown are the means and standard errors from six independent experiments.
