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. 2011 Jan;21(1):12–20. doi: 10.1101/gr.108696.110

Figure 5.

Figure 5.

mtDNA copy number and Ex4b abundance in OPA1 transcripts are coordinately regulated. (A) Mean mitochondrial genome copy number and relative abundance of the OPA1 alternate spliced exons 4, 4b, and 5b among total OPA1 transcripts in mouse brain (Br.), heart (He.), liver (Li.), and muscle (Mu.) from three animals. (B) Mean mitochondrial genome copy number and relative abundance of the alternate OPA1 exons in fibroblasts from two controls and two patients with a mitochondrial disease (n = 3, t-test; [*] P-value inferior to 0.01). (C) Mitochondrial genome copy number and relative abundance of the alternate OPA1 exons in HepG F2 rho(+) and rho(0) cells (n = 3, t-test; [*] P-value inferior to 0.01). (D) Western blot showing the expression of OPA1 in control cells and in cells overexpressing OPA1-exon4b and the corresponding quantification of mtDNA abundance (n = 3, t-test, not significant).