Figure 4.

A T/C SNP, rs6661174, at the annotated STOP codon of FMO2 leads to loss of the STOP codon (TAG to CAG). This results in a 535-residue protein, 64 amino acids longer than the annotated FMO2 protein. The C allele is present in many mammalian species and is seen predominantly in the African genomes. The homozygous C/C genotype is seen in TK1 (Khoisan African genome), and the heterozygous T/C genotype is seen in four (MD8, NB1, NA19240, and Yoruban) of the 21 personal genomes, as indicated on the right side of the figure. The SNP is labeled in red in the personal genome sequences.