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. 2010 Oct 4;286(1):243–251. doi: 10.1074/jbc.M110.139949

FIGURE 4.

FIGURE 4.

Inhibition of 6CF uptake by antivirals in oat3 knock-out adult kidney slices (function of the OAT1 transporter). Fluorescent photomicrographs show 6CF (1 μm) uptake (green) in adult oat3 KO kidney slices in the presence of a vehicle control (A), 2 mm probenecid (B), 100 μm zidovudine (C), 200 μm acyclovir (D), 100 μm tenofovir (E), 200 μm lamivudine (F), and 1 mm stavudine (G). The bar graph (H) shows relative fluorescent signal strength derived from quantitative image analysis of 6CF absorption in adult oat3 KO kidney slices. Scale bar = 0.2 mm. *, p < 0.05.