TABLE 1.

Kinetics (μm) of antiviral drugs for OAT1 (literature-based compilation of data)

Kinetic parameters (K_m, K_i, and IC₅₀) for antiviral drugs in mouse (m), rat (r), and human (h) OAT1 were analyzed in different in vitro assay systems. The individual structures of antiviral drugs are also shown. I, inhibition; S, substrate; S2, cell line from the second segment of the proximal tubule; LLC-PK1, pig renal epithelial cell; CHO, Chinese hamster ovary cells; HEK293, human embryonic kidney cell line; X. laevis, Xenopus laevis oocytes. See references below for details.