Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2010 Oct 28;286(1):403–409. doi: 10.1074/jbc.M110.181016

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© 2011 by The American Society for Biochemistry and Molecular Biology, Inc.

Author's Choice—Final version full access.

Creative Commons Attribution Non-Commercial License applies to Author Choice Articles

PMC Copyright notice

FIGURE 4. — Cellular hypersensitivity of TDP2^−/−/− cells to the Top2 poison, etoposide. A, clonogenic survival of TDP2^+/+/+, TDP2^−/−/+, and TDP2^−/−/− (clone 8) cells cultured in the indicated concentrations of etoposide. B, clonogenic survival of TDP2^+/+/+ and TDP2^−/−/− (clone 93) cells cultured as above. C, clonogenic survival of TDP2^+/+/+ cells, TDP2^−/−/− cells (clone 8), and pooled populations of TDP2^−/−/− (clone 8) transfectants harboring empty expression vector (vector) or expression vector encoding either wild-type human TDP2 (TDP2) or TDP2 with a mutated catalytic domain (TDP2 D262A). Data are the mean ± S.E. of three independent experiments. Where not visible, error bars are smaller than the symbols.