FIGURE 9.

Mouse infections by wild type and OPB(−/−) L. major. BALB/c mice (n = 5) were infected subcutaneously in the left hind footpads with wild type (solid circle) or knock-out (empty circle) L. major. Footpad swelling was measured weekly, and the footpad thickness was plotted over time. Error bars indicate the S.D. between the five mice in each group. The mice were sacrificed at 180 days postinfection. No swelling was observed in the right hind (uninfected) footpads. Significant footpad swelling occurred at 46 days PI in wild type-infected mice (p = 0.002) and 116 days postinfection in OPB knock-out-infected mice (p = 0.036).