FIGURE 2.

Full structural model of the N-terminal region of hNHE1. The structure model is based on the known structure of the smaller bacterial Na⁺/H⁺ exchanger NhaA. The shown representations include the transmembrane domains only (residues 15–31 (TM I), 104–123 (TM II), 130–147 (TM III), 160–179 (TM IV), 191–209 (TM V), 228–246 (TM VI), 255–272 (TM VII), 300–317 (TM VIII), 333–353 (TM IX), 417–437 (TM X), 453–473 (TM XI), and 481–502 (TM XII)) and exclude connecting loops and terminal extensions. The color code used is Turquoise for TMs I and II; dark blue for TMs III, IV and V; green for TMs VI, VII, VIII, and IX; and yellow for TMs X, XI and XII. A, side view of the hNHE1 structure in the plane of the lipid bilayer. B, cytoplasmic view. The inset shows the numbering of the individual helices.