TABLE 1.
Comparison of structures of human insulin, human relaxin, and bombyxin II from B. mori to the structure of DILP5
| DILP5 | Human insulin | Human relaxin | Bombyxin II | |
|---|---|---|---|---|
| PDB code | 2WFV | 1MSO | 6RLX | 1BOM |
| Sequence identity to DILP5 (%) | 100 | 27.8 | 17.2 | 20.8 |
| r.m.s.d. (Å) when superimposed on the structure of DILP5 | 0.0 | 1.6 | 1.2 | 1.3 |
| Number of equivalent C-α atoms used to superimpose molecules | 46 | 73 | 26 | 31 |
| Area of buried surface upon dimerization (Å2) | 1129.6 | 1252.8 | 1442 Å2 | N/A |
| Fraction of buried area on total solvent accessible area (%) | 17.7 | 17.2 | 20.1 | N/A |