FIGURE 1.
Sequence alignment of zebrafish gephyrin proteins with frog, avian, and mammalian counterparts. Sequence alignment of human (GenBankTM accession number NP_001019389), rat (NP_074056), mouse (modified from NP_766540), chick (NP_001026720), and frog (modified from NP_001090459) gephyrin protein (P1 isoform) with zebrafish gephyrin a (BAI68421) and gephyrin b (BAI68425). The G, C, and E domains are represented as colored boxes (G domain, green; C domain, blue; E domain, orange). The positions of C3 and C4 cassettes are indicated by open triangles. The binding sites for Pin1, Dlc1/2, and Collybistin are highlighted by yellow boxes. The GABAAR-binding site is highlighted by a magenta box. Residues essential for GlyR β interactions and Moco biosynthesis are highlighted by red and blue circles below the residues, respectively.