TABLE 1.
Enriched biological process terms for ligand-responsive phospho-proteins
Enriched GO biological process terms for ligand-responsive phospho-proteins are shown. GO terms with small p values (p < 0.05) are highlighted in bold type. Y and STY represent tyrosine and serine/threonine/tyrosine residues where altered phosphorylation was observed.
| Biological process term | Up-regulated |
Down-regulated |
||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| E2 |
HRG |
E2 |
HRG |
|||||||||||||
| Y |
STY |
Y |
STY |
Y |
STY |
Y |
STY |
|||||||||
| WT | TamR | WT | TamR | WT | TamR | WT | TamR | WT | TamR | WT | TamR | WT | TamR | WT | TamR | |
| Behavior | 1.0000 | 0.0044 | 1.0000 | 1.0000 | 1.0000 | 1.0000 | ||||||||||
| Biosynthetic process | 0.6732 | 1.0000 | 1.0000 | 0.0425 | 1.0000 | 1.0000 | 0.0000 | 1.0000 | 1.0000 | 1.0000 | 0.0093 | 1.0000 | 1.0000 | 1.0000 | ||
| Cell communication | 1.0000 | 1.0000 | 1.0000 | 1.0000 | 0.0003 | 0.0006 | 0.1828 | 1.0000 | 1.0000 | 1.0000 | 1.0000 | 1.0000 | 0.1894 | 1.0000 | 1.0000 | |
| Cell cycle | 1.0000 | 1.0000 | 0.0007 | 0.4405 | 0.0032 | 0.0051 | 0.1074 | 0.0126 | 0.3103 | 0.0735 | 1.0000 | 0.0976 | 1.0000 | |||
| Cellular component organization | 1.0000 | 1.0000 | 0.1769 | 0.6265 | 1.0000 | 0.0841 | 0.8058 | 0.0000 | 0.0006 | 0.0015 | 0.0988 | 0.0006 | 1.0000 | 0.0355 | 0.0812 | |
| Cytoskeleton organization | 1.0000 | 1.0000 | 1.0000 | 0.0238 | 0.9275 | 0.0000 | 0.0001 | 1.0000 | 1.0000 | 0.0029 | 1.0000 | 1.0000 | 1.0000 | |||
| Lipid metabolic process | 1.0000 | 1.0000 | 0.0334 | 1.0000 | 1.0000 | 1.0000 | 1.0000 | 1.0000 | 1.0000 | 1.0000 | ||||||
| Metabolic process | 0.2821 | 1.0000 | 1.0000 | 0.0055 | 0.0274 | 1.0000 | 1.0000 | 0.0000 | 1.0000 | 0.0023 | 0.0068 | 0.0001 | 1.0000 | 0.0253 | 0.0389 | |
| Multicellular organismal development | 0.7201 | 1.0000 | 1.0000 | 1.0000 | 0.0092 | 1.0000 | 1.0000 | 0.0137 | 1.0000 | 1.0000 | 1.0000 | 0.0291 | 1.0000 | 1.0000 | ||
| Nucleobase, nucleoside, nucleotide, and nucleic acid metabolic process | 0.1250 | 1.0000 | 0.3810 | 0.8876 | 1.0000 | 0.4460 | 1.0000 | 0.0001 | 1.0000 | 0.0000 | 0.0000 | 0.1370 | 1.0000 | 0.0000 | 0.0000 | |
| Organelle organization | 0.1646 | 1.0000 | 1.0000 | 0.1420 | 1.0000 | 0.0772 | 0.4538 | 0.0000 | 0.0007 | 0.0133 | 0.3095 | 0.0000 | 1.0000 | 0.7556 | 0.3428 | |
| Primary metabolic process | 0.1025 | 1.0000 | 0.7279 | 0.0010 | 0.0132 | 1.0000 | 1.0000 | 0.0000 | 1.0000 | 0.0001 | 0.0009 | 0.0000 | 1.0000 | 0.0027 | 0.0100 | |
| Protein metabolic process | 1.0000 | 1.0000 | 1.0000 | 0.0000 | 0.0001 | 1.0000 | 1.0000 | 0.0000 | 0.7278 | 1.0000 | 0.0001 | 1.0000 | 1.0000 | 1.0000 | ||
| Regulation of biological process | 1.0000 | 1.0000 | 1.0000 | 0.2572 | 0.0187 | 0.0008 | 0.1117 | 1.0000 | 0.3626 | 0.0124 | 0.0201 | 1.0000 | 0.6949 | 0.0958 | 1.0000 | |
| Response to external stimulus | 1.0000 | 1.0000 | 0.0010 | 1.0000 | 1.0000 | 1.0000 | 1.0000 | 1.0000 | 1.0000 | 1.0000 | 1.0000 | |||||
| Response to stress | 1.0000 | 1.0000 | 1.0000 | 0.9745 | 0.0136 | 1.0000 | 1.0000 | 0.0003 | 0.0204 | 1.0000 | 1.0000 | 0.2076 | 1.0000 | 1.0000 | ||
| Signal transduction | 1.0000 | 1.0000 | 1.0000 | 1.0000 | 0.00001 | 0.0002 | 0.3849 | 1.0000 | 1.0000 | 1.0000 | 1.0000 | 1.0000 | 0.1219 | 1.0000 | 1.0000 | |
| Translation | 0.0001 | 0.0000 | 1.0000 | 0.0000 | 1.0000 | 1.0000 | 0.0000 | 1.0000 | 1.0000 | |||||||
| Viral reproduction | 0.0439 | 1.0000 | 0.6691 | 0.2014 | ||||||||||||