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. 2010 Dec 31;5(12):e14338. doi: 10.1371/journal.pone.0014338

Table 3. The area under the curve (AUC) for the different interaction scenarios.

Simulated Interaction Factor 21 Simulated Interaction Factor 102
Interaction risk estimate GCI risk estimate (Multiplicative) Interaction risk estimate GCI risk estimate (Multiplicative)
Crohn's Disease 0.722 0.722 0.739 0.724
Rheumatoid Arthritis 0.679 0.674 0.720 0.673
Type 2 Diabetes 0.597 0.594 0.607 0.595

1. The two columns correspond to the case where there is a SNP-SNP interaction in which the effect of a certain combination of genotypes has two times the product of the marginal effects.

2. The two columns correspond to the case where there is a SNP-SNP interaction in which the effect of a certain combination of genotypes is 10 times the product of the marginal effects.