Skip to main content
. 2010 Dec 31;5(12):e15962. doi: 10.1371/journal.pone.0015962

Table 1. Tumor-to-organ ratios.

Tumor to organ Ratio 15 min 60 min 240 min 15 min blocking 60 min blocking
Blood 0.541±0.064 0.652±0.244 0.565±0.119 0.419±0.046 0.497±0.078
Heart 1.664±0.191 2.506±1.980 1.551±0.282 1.289±0.232 1.423±0.330
Lung 0.744±0.096 1.232±1.245 0.818±0.207 0.587±0.079 0.674±0.178
Spleen 1.258±0.142 1.585±1.122 1.095±0.240 1.007±0.143 1.152±0.117
Liver 1.248±0.138 1.813±1.095 1.239±0.223 0.907±0.121 1.226±0.232
Kidney 0.474±0.088 0.797±0.510 0.611±0.144 0.333±0.079 0.501±0.078
Muscle 2.529±0.310 4.111±2.444 2.781±0.599 1.884±0.463 2.623±0.264
Intestinum 1.299±0.301 1.396±0.546 0.859±0.492 1.145±0.069 0.864±0.226
Brain 7.736±1.066 17.60±9.740 17.19±5.018 6.631±1.725 9.71±4.034

Tumor-to-organ ratios were calculated from the organ distribution of 131I-CaIX-P1 in female Balb/c nu/nu mice carrying SKRC 52 tumors after 15 min (n = 8 animals), 60 min (n = 10 animals) and 240 min (n = 3 animals) circulation of the radioligand in the blood stream. For in vivo blocking, 100 µL unlabeled peptide at a concentration of 10−3 M was co-injected with the radioligand and tumor-to-organ ratios were calculated after 15 min (n = 3 animals) and 60 min (n = 3 animals) circulation in the blood stream.