Table 1. Tumor-to-organ ratios.
Tumor to organ Ratio | 15 min | 60 min | 240 min | 15 min blocking | 60 min blocking |
Blood | 0.541±0.064 | 0.652±0.244 | 0.565±0.119 | 0.419±0.046 | 0.497±0.078 |
Heart | 1.664±0.191 | 2.506±1.980 | 1.551±0.282 | 1.289±0.232 | 1.423±0.330 |
Lung | 0.744±0.096 | 1.232±1.245 | 0.818±0.207 | 0.587±0.079 | 0.674±0.178 |
Spleen | 1.258±0.142 | 1.585±1.122 | 1.095±0.240 | 1.007±0.143 | 1.152±0.117 |
Liver | 1.248±0.138 | 1.813±1.095 | 1.239±0.223 | 0.907±0.121 | 1.226±0.232 |
Kidney | 0.474±0.088 | 0.797±0.510 | 0.611±0.144 | 0.333±0.079 | 0.501±0.078 |
Muscle | 2.529±0.310 | 4.111±2.444 | 2.781±0.599 | 1.884±0.463 | 2.623±0.264 |
Intestinum | 1.299±0.301 | 1.396±0.546 | 0.859±0.492 | 1.145±0.069 | 0.864±0.226 |
Brain | 7.736±1.066 | 17.60±9.740 | 17.19±5.018 | 6.631±1.725 | 9.71±4.034 |
Tumor-to-organ ratios were calculated from the organ distribution of 131I-CaIX-P1 in female Balb/c nu/nu mice carrying SKRC 52 tumors after 15 min (n = 8 animals), 60 min (n = 10 animals) and 240 min (n = 3 animals) circulation of the radioligand in the blood stream. For in vivo blocking, 100 µL unlabeled peptide at a concentration of 10−3 M was co-injected with the radioligand and tumor-to-organ ratios were calculated after 15 min (n = 3 animals) and 60 min (n = 3 animals) circulation in the blood stream.