| • Residence in region with known high MDR/XDR TB prevalence |
| • Known exposure to MDR/XDR TB patient |
| • HIV/AIDS |
| • History of: |
| ◦ previous TB therapy, especially within the past year |
| ◦ relapse or recurrence after previous successful treatment |
| ◦ hospitalization within the past two years |
| ◦ nonadherence or default |
| ◦ incarceration |
| ◦ substance abuse or attendance of addiction treatment facilities |
| ◦ kanamycin resistance |
| ◦ malabsorption |
| ◦ medications known to cause drug interactions with concurrent TB therapy |
