. Author manuscript; available in PMC: 2011 Jul 1.

Published in final edited form as: Cancer Epidemiol Biomarkers Prev. 2010 Jun 22;19(7):1822–1830. doi: 10.1158/1055-9965.EPI-09-1317

Table 3. Associations^* of a per-allele increase in TYMS rs495139 and risk of ovarian carcinoma types among white non-Hispanic subjects in OCAC.

Studies	Co	Serous			Mucinous			Endometrioid			Clear Cell

		Ca	OR (95% CI)	P trend	Ca	OR (95% CI)	P trend	Ca	OR (95% CI)	P trend	Ca	OR (95% CI)	P trend	P value^†
15 OCAC studies^‡	8,410	2,823	1.06 (1.00-1.13)	0.05	354	1.19 (1.03-1.39)	0.02	821	0.90 (0.81-0.99)	0.04	409	0.86 (0.75-0.99)	0.04	0.001

15 OCAC studies^§	8,410	1,775	1.02 (0.94-1.10)	0.68	204	1.26 (1.04-1.54)	0.02	515	0.94 (0.83-1.07)	0.36	409	0.86 (0.74-0.99)	0.04	0.04

15 OCAC studies^§, “re-assigned” type	8,410	1,972	1.02 (0.95-1.09)	0.62	183	1.32 (1.07-1.62)	0.01	318	0.92 (0.78-1.08)	0.29	409	0.86 (0.74-0.99)	0.04	0.04

Co, controls; Ca, cases

Bold text indicates statistically significant associations

Adjusted for age and study

^†

P for tumor heterogeneity

^‡

All OCAC studies including MAY and NCO1 but excluding MAL, which failed genotyping; samples do not total 5,593 cases and 9,962 controls from application of quality control criteria (see Methods) and exclusion of rarer histologies

^§

Cases further restricted to samples with information on grade

Table 3. Associations* of a per-allele increase in TYMS rs495139 and risk of ovarian carcinoma types among white non-Hispanic subjects in OCAC.

Table 3. Associations^* of a per-allele increase in TYMS rs495139 and risk of ovarian carcinoma types among white non-Hispanic subjects in OCAC.