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. Author manuscript; available in PMC: 2011 Jan 3.
Published in final edited form as: J Neurophysiol. 2008 Apr 9;99(6):3052–3062. doi: 10.1152/jn.90301.2008

Figure 3.

Figure 3

PKC Activation Uncouples NR2A from PSD-95 in Mature Neurons. A. Representative blot of co-immunoprecipitation. PSD-95 band density was significantly reduced in IP lanes with TPA alone or TPA plus 2-BP treatments compared to control. B. 1-hr TPA treatment of mature neurons significantly uncoupled PSD-95 from NR2A similarly to 6-hr 2-BP treatments. Combined 1-hr TPA and 6-hr 2-BP treatment did not produce additive reduction in NR2A/PSD-95 association. n=8 independent experiments with all four conditions done in parallel; *P<0.05, **P<0.01 by one-way ANOVA followed by Bonferroni post-test.