Table 2.

Result of meta-analysis for selected SNPs

Chr	SNPs	Position	m/M alleles	Risk allele	Fixed effect		Random effect			Heterogeneity		Genetic variation
					OR	95% CI	OR	95% CI	P-valofZ	P-valofQ	I2	Freq	Proportion
2	rs1465618	43,407,453	A/G	A	1.11	1.07 – 1.16	1.15	1.04 – 1.26	4.92E-03	8.66E-03	79%	0.212	0.003
2	rs721048	62,985,235	A/G	A	1.16	1.11 – 1.22	1.18	1.10 – 1.28	1.22E-05	0.084	44%	0.137	0.002
2	rs12621278	173,019,799	A/G	A	1.35	1.27 – 1.44	1.35	1.27 – 1.44	3.36E-19	0.576	0%	0.960	0.003
3	rs2660753	87,193,364	T/C	T	1.22	1.14 – 1.31	1.24	1.04 – 1.48	0.015	3.87E-04	84%	0.102	0.003
3	rs10934853	129,521,063	A/C	A	1.12	1.08 – 1.16	1.12	1.06 – 1.18	7.43E-05	0.016	53%	0.239	0.002
4	rs17021918	95,781,900	T/C	C	1.14	1.10 – 1.18	1.14	1.10 – 1.18	1.54E-15	0.473	0%	0.646	0.003
4	rs7679673	106,280,983	A/C	C	1.13	1.10 – 1.17	1.14	1.09 – 1.20	1.29E-07	0.153	47%	0.624	0.003
6	rs9364554	160,753,654	T/C	T	1.16	1.10 – 1.21	1.17	1.06 – 1.29	1.91E-03	5.96E-03	76%	0.274	0.004
7	rs6465657	97,654,263	T/C	C	1.13	1.08 – 1.18	1.14	1.05 – 1.23	1.42 E-03	0.031	66%	0.509	0.003
8	rs2928679	23,494,920	A/G	A	1.09	1.06 – 1.12	1.13	1.02 – 1.25	0.017	3.89E-04	87%	0.456	0.003
8	rs1512268	23,582,408	T/C	T	1.17	1.14 – 1.21	1.17	1.12 – 1.23	1.56E-12	0.205	37%	0.420	0.005
8	rs10086908	128,081,119	C/T	T	1.13	1.09 – 1.18	1.13	1.08 – 1.19	6.25E-07	0.243	23%	0.625	0.003
8	rs16901979	128,194,098	A/C	A	1.80	1.57 – 2.06	1.82	1.44 – 2.30	6.32E-07	0.163	41%	0.031	0.009
8	rs16902094	128,389,528	G/A	G	1.21	1.16 – 1.27	1.20	1.12 – 1.30	1.12E-06	0.015	54%	0.271	0.005
8	rs620861	128,404,855	A/G	G	1.16	1.11 – 1.20	1.16	1.11 – 1.20	1.18E-13	0.618	0%	0.619	0.004
8	rs6983267	128,482,487	G/T	G	1.20	1.14 – 1.26	1.20	1.14 – 1.26	8.13E-12	0.758	0%	0.487	0.006
8	rs1447295	128,554,220	A/C	A	1.49	1.40 – 1.57	1.47	1.33 – 1.62	3.82E-14	0.013	57%	0.071	0.008
10	rs10993994	51,219,502	T/C	T	1.26	1.22 – 1.31	1.25	1.12 – 1.40	6.80E-05	1.22E-15	91%	0.341	0.009
10	rs4962416	126,686,862	C/T	C	1.14	1.09 – 1.20	1.15	1.04 – 1.27	7.85 E-03	1.79E-04	80%	0.257	0.003
11	rs7127900	2,190,150	G/A	A	1.25	1.20 – 1.30	1.25	1.20 – 1.30	<1.00E-30	0.713	0%	0.235	0.007
11	rs10896449	68,751,243	A/G	G	1.16	1.11 – 1.22	1.16	1.11 – 1.22	8.67E-10	0.898	0%	0.532	0.004
17	rs11649743	33,149,092	A/G	G	1.16	1.11 – 1.22	1.16	1.11 – 1.22	1.19E-09	0.922	0%	0.757	0.003
17	rs4430796	33,172,153	A/G	A	1.22	1.17 – 1.26	1.22	1.17 – 1.26	1.13E-25	0.645	0%	0.491	0.008
17	rs1859962	66,620,348	G/T	G	1.20	1.13 – 1.27	1.21	1.12 – 1.30	7.94E-07	0.214	33%	0.527	0.007
19	rs8102476	43,427,453	T/C	C	1.12	1.08 – 1.15	1.12	1.08 – 1.15	2.27E-12	0.729	0%	0.504	0.002
19	rs887391	46,677,464	C/T	T	1.14	1.08 – 1.20	1.14	1.08 – 1.20	6.86E-07	0.826	0%	0.757	0.003
19	rs2735839	56,056,435	A/G	G	1.30	1.22 – 1.39	1.30	1.11 – 1.51	7.47E-04	6.37E-04	83%	0.863	0.006
22	rs9623117	38,782,065	C/T	C	1.12	1.07 – 1.17	1.13	1.05 – 1.22	1.22E-03	0.019	58%	0.221	0.002
22	rs5759167	41,830,156	T/G	G	1.18	1.14 – 1.21	1.18	1.14 – 1.21	1.44E-27	0.682	0%	0.549	0.005
23	rs5945619	51,258,412	C/T	C	1.26	1.18 – 1.34	1.27	1.12 – 1.43	2.05E-04	0.012	73%	0.385	0.005

m = minor allele, M = major allele; OR and 95% CI were calculated in terms of risk allele; and Freq is the risk allele freq in HapMap.