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. Author manuscript; available in PMC: 2012 Jan 1.
Published in final edited form as: Arterioscler Thromb Vasc Biol. 2010 Oct 14;31(1):81–85. doi: 10.1161/ATVBAHA.110.213496

Figure 3. Myeloid S1PR2 mediates pro-atherosclerotic effects.

Figure 3

(A) En face Oil Red O staining analysis of aortae upon transplantation of Apoe−/−S1pr2+/+ (n=6) or Apoe−/−S1pr2−/−(n=13) bone marrow cells to Apoe−/−S1pr2+/+ recipients. Mice were placed on high fat diet for 13 weeks and analyzed as described. (B) Quantification of en face analysis of atherosclerotic plaques. (P < 0.0001). (C) MOMA-2 (monocytes and macrophages) and Oil Red O (lipid accumulation) staining in aortic root lesions from Apoe−/−S1pr2+/+ (n=3) or Apoe−/−S1pr2−/− (n=3) bone marrow transplanted to Apoe−/− S1pr2+/+ recipients and placed on high fat diet for 13 weeks. Scale bar, 100µm. (D) Quantitative analysis of aortic root lesions. Lipid accumulation (P < 0.04) and inflammatory component (P < 0.03) of the plaque were significantly reduced in Apoe−/−S1pr2+/+ animals transplanted with Apoe−/−S1pr2−/− bone marrow cells.