Table II. A list of proteins decreased in abundance in mpkCCD cells in response to long-term (5 days) 0.1 nM dDAVP exposure. Results were calculated from all peptides quantified using SILAC in three LTQ-FT-ICR data-dependent experiments. Shown are log₂ values of the mean of all peptide ratios (dDAVP: vehicle or D/V). All passed two-tailed t-test against log₂(1) (p < 0.05).

Protein name	Gene symbol	RefSeq no.	No. of peptides	Log2(D/V) (Mean ± S.E.)
mediator of DNA damage checkpoint 1	Mdc1	NP_001010833	3	−1.5 ± 0.1
DNA methyltransferase (cytosine-5) 1	Dnmt1	NP_034196	16	−1.2 ± 0.3
myosin, light polypeptide kinase	Mylk	NP_647461	13	−1.1 ± 0.3
nucleoporin 210	Nup210	NP_061285	11	−1.0 ± 0.3
pinin	Pnn	NP_032917	5	−0.9 ± 0.2
gelsolin	Gsn	NP_666232	22	−0.9 ± 0.1
basal cell adhesion molecule	Bcam	NP_065232	4	−0.9 ± 0.1
FK506 binding protein 5	Fkbp5	NP_034350	1	−0.8 ± 0.2
PREDICTED: desmoplakin isoform 2	Dsp	XP_901443	18	−0.8 ± 0.2
glycerol-3-phosphate dehydrogenase 1 (soluble)	Gpd1	NP_034401	10	−0.7 ± 0.1
D6Wsu176e protein	Fam3c	NP_613053	3	−0.7 ± 0.1
myristoylated alanine rich protein kinase C substrate	Marcks	NP_032564	6	−0.7 ± 0.1
ladinin	Lad1	NP_598425	7	−0.6 ± 0.2
minichromosome maintenance deficient 2 mitotin	Mcm2	NP_032590	32	−0.6 ± 0.2
adenine phosphoribosyltransferase	Aprt	NP_033828	6	−0.6 ± 0.1
cadherin 16	Cdh16	NP_031689	12	−0.6 ± 0.1
PDZ and LIM domain 5 isoform ENH1	Pdlim5	NP_062782	9	−0.6 ± 0.1
Rho, GDP dissociation inhibitor (GDI) beta	Arhgdib	NP_031512	4	−0.6 ± 0.1
H1 histone family, member 0	H1f0	NP_032223	4	−0.6 ± 0.1
cystatin B	Cstb	NP_031819	4	−0.5 ± 0.2
membrane bound C2 domain containing protein	Mbc2	NP_035973	2	−0.5 ± 0.2
minichromosome maintenance deficient 5, cell division cycle 46	Mcm5	NP_032592	27	−0.5 ± 0.2
guanine monophosphate synthetase	Gmps	NP_001028472	9	−0.5 ± 0.2
synaptotagmin binding, cytoplasmic RNA interacting protein isoform 2	Syncrip	NP_062770	10	−0.5 ± 0.1
minichromosome maintenance complex component 6	Mcm6	NP_032593	20	−0.5 ± 0.1
activity-dependent neuroprotective protein	Adnp	NP_033758	3	−0.5 ± 0.1
suppressor of Ty 16 homolog	Supt16h	NP_291096	14	−0.5 ± 0.1
annexin A6 isoform a	Anxa6	NP_038500	38	−0.5 ± 0.1
estradiol 17-beta-dehydrogenase 11	Hsd17b11	NP_444492	5	−0.5 ± 0.1
thymopoietin isoform delta	Tmpo	NP_001073599	15	−0.5 ± 0.1
sterile alpha motif domain containing 9-like	Samd9l	NP_034286	29	−0.5 ± 0.1
minichromosome maintenance complex component 7	Mcm7	NP_032594	22	−0.5 ± 0.1
integrin beta 1 (fibronectin receptor beta)	Itgb1	NP_034708	12	−0.4 ± 0.1
isocitrate dehydrogenase 2 (NADP+), mitochondrial	Idh2	NP_766599	12	−0.4 ± 0.1
filamin B, beta	Flnb	NP_598841	92	−0.4 ± 0.1
activator of heat shock 90kDa protein ATPase homolog 1	Ahsa1	NP_666148	3	−0.4 ± 0.1
integrin alpha 3	Itga3	NP_038593	9	−0.4 ± 0.1
apoptotic chromatin condensation inducer 1 isoform 2	Acin1	NP_075679	5	−0.4 ± 0.1
transcription elongation factor A (SII) 1 isoform 2	Tcea1	NP_035671	2	−0.4 ± 0.1
glutathione S-transferase, alpha 3	Gsta3	NP_034486	8	−0.4 ± 0.1
annexin A2	Anxa2	NP_031611	24	−0.4 ± 0.1
dihydropyrimidinase-like 2	Dpysl2	NP_034085	13	−0.4 ± 0.1
vinculin	Vcl	NP_033528	42	−0.4 ± 0.1
filamin C, gamma	Flnc	NP_001074654	16	−0.4 ± 0.1
unc-84 homolog B	Unc84b	NP_919323	2	−0.4 ± 0.1
glyoxalase 1	Glo1	NP_079650	5	−0.3 ± 0.1
heterogeneous nuclear ribonucleoprotein U	Hnrnpu	NP_058085	28	−0.3 ± 0.1
KH-type splicing regulatory protein	Khsrp	NP_034743	18	−0.3 ± 0.1
protein disulfide isomerase A6	Pdia6	NP_082235	8	−0.3 ± 0.1
cytochrome c oxidase, subunit Va	Cox5a	NP_031773	7	−0.3 ± 0.1
splicing factor 3a, subunit 2	Sf3a2	NP_038679	2	−0.3 ± 0.1
chromodomain helicase DNA binding protein 4	Chd4	NP_666091	49	−0.3 ± 0.1
arsenate resistance protein 2 isoform 1	Srrt	NP_113582	10	−0.3 ± 0.1
U5 snRNP-specific protein, 200 kDa	Snrnp200	NP_796188	46	−0.3 ± 0.1
protein disulfide isomerase A4	Pdia4	NP_033917	22	−0.3 ± 0.1
cytochrome c oxidase subunit IV isoform 1	Cox4i1	NP_034071	5	−0.3 ± 0.1
importin 5	Ipo5	NP_076068	6	−0.3 ± 0.1
adaptor protein complex AP-1, gamma 1 subunit	Ap1g1	NP_033807	8	−0.3 ± 0.1
tumor rejection antigen gp96	Hsp90b1	NP_035761	31	−0.3 ± 0.1
serine hydroxymethyltransferase 2 (mitochondrial)	Shmt2	NP_082506	12	−0.3 ± 0.1
apoptosis-inducing factor, mitochondrion-associated 1	Aifm1	NP_036149	7	−0.3 ± 0.1
LPS-responsive beige-like anchor isoform alpha	Lrba	NP_109620	68	−0.3 ± 0.1
l-3-hydroxyacyl-Coenzyme A dehydrogenase	Hadh	NP_032238	11	−0.3 ± 0.1
integral membrane protein 1	Stt3a	NP_032434	3	−0.3 ± 0.1
alpha thalassemia/mental retardation syndrome X-linked homolog	Atrx	NP_033556	1	−0.3 ± 0.1
FK506 binding protein 52	Fkbp4	NP_034349	10	−0.3 ± 0.1
peptidylprolyl isomerase B	Ppib	NP_035279	14	−0.3 ± 0.1
NADH dehydrogenase ubiquinone flavoprotein 2 precursor	Ndufv2	NP_082664	1	−0.3 ± 0.1
protease (prosome, macropain) 26S subunit, ATPase 5	Psmc5	NP_032976	2	−0.2 ± 0.1
nuclear pore complex-associated protein Tpr	Tpr	NP_598541	29	−0.2 ± 0.1
splicing factor, arginine/serine-rich 7	Sfrs7	NP_666195	5	−0.2 ± 0.1
gelsolin-like capping protein isoform 1	Capg	NP_031625	11	−0.2 ± 0.1
karyopherin (importin) beta 1	Kpnb1	NP_032405	28	−0.2 ± 0.1
small nuclear ribonucleoprotein E	Snrpe	NP_033253	1	−0.2 ± 0.1
nucleolin	Ncl	NP_035010	21	−0.2 ± 0.1
DEAH (Asp-Glu-Ala-His) box polypeptide 9	Dhx9	NP_031868	35	−0.2 ± 0.1
voltage-dependent anion channel 3	Vdac3	NP_035826	7	−0.2 ± 0.1
HLA-B-associated transcript 3	Bat3	NP_476512	7	−0.2 ± 0.1
heterogeneous nuclear ribonucleoprotein A1 isoform a	Hnrnpa1	NP_034577	16	−0.2 ± 0.1
SEC22 vesicle trafficking protein-like 1	Sec22b	NP_035472	5	−0.2 ± 0.1
nucleoside diphosphate kinase B	Nme2	NP_032731	9	−0.2 ± 0.1
splicing factor 3b, subunit 3	Sf3b3	NP_598714	26	−0.2 ± 0.1
pre-mRNA processing factor 8	Prpf8	NP_619600	39	−0.1 ± 0.1
PREDICTED: similar to Heat shock protein 1 (chaperonin)	Hspd1	XP_484008	25	−0.1 ± 0.1
ribosomal protein L18	Rpl18	NP_033103	6	−0.1 ± 0.1
voltage-dependent anion channel 1	Vdac1	NP_035824	14	−0.1 ± 0.1