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Post-translational protein deactivation using chemical inducers of dimerization. A rapamycin-analogue (FK1012-A) approach is depicted. A) In the presence of FK1012-A, FK506-binding protein (FKBP) forms dimeric complexes, which inhibits the activity of some proteins. B) In the absence of FK1012-A, FKBP becomes monomeric, which restores protein activity.
