Table 3.

SNPs with suggestive associations (COHORT1, n = 794)

SNP ID	Gene	Chromosome	Physical Location (bp)	eGFR Pa	Renal Survival Pb	Alleles	Reference Allele	RAFc	HapMap RAFd	HWE P	Marker Missing (%)	GenCall Scoree
rs3750940	DKK3	11	11979474	0.00019	0.22	A/G	G	0.20	0.21	0.56	0.24	0.82
rs7104941	DKK3	11	11977192	0.0027	0.27	G/A	A	0.19	0.17	0.24	0.24	0.74
rs12575803	DKK3	11	11981152	0.00019	0.55	C/A	A	0.14	0.14	0.59	0.48	0.92
rs875588	RHEB	7	150799763	0.0017	0.27	G/A	A	0.48	0.48	0.57	0.12	0.83
rs3753151	RHEB	7	150815918	0.0051	0.30	G/A	A	0.53	0.57	0.37	0.72	0.78
rs6972955	RHEB	7	150802595	0.0022	0.47	C/A	A	0.44	0.48	0.95	0.24	0.81
rs6546365	PPP3R1	2	68328790	0.0015	0.012	G/A	A	0.48	0.43	0.67	1.10	0.77
rs1693869	CALM2	2	47255568	0.23	0.0034	G/C	C	0.12	0.13	0.80	0.00	0.86
rs815802	CALM2	2	47245553	0.72	0.0046	A/G	G	0.09	0.08	0.43	0.24	0.86
rs2206593	PTGS2	1	184909052	0.53	0.0016	G/A	A	0.08	0.06	0.69	0.60	0.85
rs3917225	IL1R1	2	102135734	0.21	0.0019	A/G	G	0.48	0.46	0.83	0.24	0.86
rs4150471	ERCC3	2	127751009	0.52	0.0036	G/A	A	0.28	0.23	1.00	0.36	0.90

HWE, Hardy-Weinberg equilibrium; RAF, reference allele frequency.

^aAdjusted for age, MDS dimensions C1 through C4, and family relationship by GEE.

^bCox proportional hazards model was used for renal survival (absence of ESRD) analysis; adjusted for MDS dimensions C1 through C4 and family relationship.

^cRAF was derived from a random draw of one genotyped individual from each family.

^dRAF from the HapMap database for European population.

^eThe GenCall scores ≥0.7 indicate well-behaving genotypes.