Table 4.

Replication of SNPs with suggestive associations (COHORT2, n = 472)

SNP ID	Gene	Chromosome	Physical Location (bp)	eGFR Pa	Renal Survival Pb	Alleles	Reference Allele	RAFc	HapMap RAFd	HWE P	Marker Missing (%)
rs3750940	DKK3	11	11979474	0.067	0.43	A/G	G	0.17	0.21	0.05	0.0
rs7104941	DKK3	11	11977192	0.070	0.23	G/A	A	0.16	0.17	0.11	0.0
rs12575803	DKK3	11	11981152	0.22	0.70	C/A	A	0.12	0.14	1.00	4.3
rs875588	RHEB	7	150799763	0.25	0.97	G/A	A	0.52	0.48	0.13	1.7
rs3753151	RHEB	7	150815918	0.39	0.74	G/A	A	0.58	0.57	0.19	0.0
rs6972955	RHEB	7	150802595	0.11	0.61	C/A	A	0.42	0.42	0.06	0.0
rs6546365	PPP3R1	2	68328790	0.36	0.22	G/A	A	0.44	0.43	0.59	0.0
rs1693869	CALM2	2	47255568	0.59	0.84	G/C	C	0.12	0.13	0.38	0.0
rs815802	CALM2	2	47245553	0.26	0.47	A/G	G	0.10	0.08	0.38	0.0
rs2206593	PTGS2	1	184909052	0.98	0.84	G/A	A	0.05	0.06	0.30	0.0
rs3917225	IL1R1	2	102135734	0.69	0.76	A/G	G	0.48	0.46	0.95	0.0
rs4150471	ERCC3	2	127751009	0.059	0.96	G/A	A	0.27	0.23	0.51	0.4

HWE, Hardy-Weinberg equilibrium; RAF, reference allele frequency.

^aAdjusted for age and family relationship by GEE.

^bCox proportional hazards model for renal survival analysis; adjusted for family relationship.

^cRAF was derived from a random draw of one genotyped individual from each family.

^dRAF from the HapMap database for European population.