Table 5.

Combined analysis of cohorts 1 and 2 (n = 1266) by GEE

SNP ID	Gene	Chromosome	Physical Location (bp)	Reference Allele	RAFa	eGFR Pb	Effect (95% CI)c	Renal Survival Pd	Effect (95% CI)
rs3750940	DKK3	11	11979474	G	0.21	8.0 × 10−5	−8.000 (−12.000 to −4.000)	0.095	0.090 (−0.020 to 0.200)
rs7104941	DKK3	11	11977192	A	0.20	6.2 × 10−4	−7.300 (−12.000 to −3.100)	0.059	0.110 (−0.004 to 0.220)
rs12575803	DKK3	11	11981152	A	0.15	4.2 × 10−4	−8.700 (−13.000 to −3.900)	0.70	0.025 (−0.100 to 0.150)
rs875588	RHEB	7	150799763	A	0.50	0.046	3.600 (0.060 to 7.000)	0.56	−0.025 (−0.110 to 0.057)
rs3753151	RHEB	7	150815918	A	0.56	0.073	3.300 (−0.310 to 7.000)	0.79	−0.011 (−0.095 to 0.072)
rs6972955	RHEB	7	150802595	A	0.44	0.050	3.600 (0.003 to 7.200)	0.48	−0.028 (−0.100 to 0.049)
rs6546365	PPP3R1	2	68328790	A	0.40	2.9 × 10−3	4.700 (1.600 to 7.800)	5.7 × 10−3	−0.100 (−0.170 to −0.030)
rs1693869	CALM2	2	47255568	C	0.14	0.26	−2.600 (−7.300 to 2.000)	0.014	0.160 (0.030 to 0.280)
rs815802	CALM2	2	47245553	G	0.11	0.59	−1.400 (−6.700 to 3.800)	8.6 × 10−3	0.180 (0.040 to 0.310)
rs2206593	PTGS2	1	184909052	A	0.05	0.37	3.000 (−3.600 to 9.700)	0.075	−0.140 (−0.290 to 0.014)
rs3917225	IL1R1	2	102135734	G	0.47	0.20	−2.300 (−5.700 to 1.200)	0.013	0.100 (0.020 to 0.180)
rs4150471	ERCC3	2	127751009	A	0.27	0.73	−0.730 (−4.800 to 3.400)	0.033	0.100 (0.008 to 0.200)

CI, confidence interval; RAF, reference allele frequency.

^aRAF was derived from a random draw of one genotyped individual from each family.

^bAdjusted for age and family relationship by GEE.

^cProvides an estimate of the effect size of the reference allele under an additive model.

^dCox proportional hazards model for renal survival analysis, adjusted for family relationship.