Table 6.

Combined analysis of cohorts 1 and 2 (n = 1266) by Merlin

SNP ID	Gene	Chromosome	Physical Location (bp)	Reference Allele	RAFa	eGFR Pb	H2 (%)c	Renal Survival Pd	H2 (%)
rs3750940	DKK3	11	11979474	G	0.21	4.6 × 10−5	1.40	0.24	0.13
rs7104941	DKK3	11	11977192	A	0.20	1.4 × 10−4	1.30	0.12	0.23
rs12575803	DKK3	11	11981152	A	0.15	6.7 × 10−4	0.95	0.92	0.00
rs875588	RHEB	7	150799763	A	0.50	0.14	0.21	0.97	0.00
rs3753151	RHEB	7	150815918	A	0.56	0.20	0.16	0.91	0.00
rs6972955	RHEB	7	150802595	A	0.44	0.052	0.37	0.77	0.01
rs6546365	PPP3R1	2	68328790	A	0.40	0.0081	0.57	0.052	0.35
rs1693869	CALM2	2	47255568	C	0.14	0.12	0.27	0.044	0.47
rs815802	CALM2	2	47245553	G	0.11	0.25	0.15	0.020	0.63
rs2206593	PTGS2	1	184909052	A	0.05	0.44	0.06	0.19	0.17
rs3917225	IL1R1	2	102135734	G	0.47	0.11	0.23	0.047	0.38
rs4150471	ERCC3	2	127751009	A	0.27	0.63	0.02	0.037	0.95

RAF, reference allele frequency.

^aRAF was derived from a random draw of one genotyped individual from each family.

^bRank transformed and adjusted for age and family relationship by the variance components association method in Merlin.

^cProportion of the variance estimated to be accounted for by the marker.

^dCox proportional hazards model for renal survival analysis, rank transformed and adjusted for family relationship by the variance components association method.