Table 1.
Transgenic parameters characterized
Parameter | WT Littermate Controls | Heterozygous Animals | Homozygous Animals |
---|---|---|---|
Glomerular volume (μl) | 0.98 ± 0.16 (n = 8) | 0.73 ± 0.07 (n = 18) | 1.56 ± 0.11 (n = 36) |
LpA | 1.93 ± 0.32 (n = 8) | 1.00 ± 0.12 (n = 18) | 1.06 ± 0.16 (n = 23) |
LpA/Vi | 1.95 ± 0.17 (n = 8) | 1.44 ± 0.11 (n = 18) | 0.67 ± 0.07 (n = 23) |
uPCR (mg/mmol) | 20.16 ± 2.55 (n = 8) | 20.74 ± 2.80 (n = 10) | 14.80 ± 2.78 (n = 3) |
Plasma creatinine (μmol/L) | 3.40 ± 1.21 (n = 5) | 4.50 ± 1.20 (n = 6) | 6.00 ± 1.53 (n = 3) |
Plasma urea (mmol/L) | 8.60 ± 0.10 (n = 5) | 9.32 ± 0.50 (n = 6) | 11.07 ± 0.90 (n = 3) |
GFR (μl/min) | 306.70 ± 57.50 (n = 4) | 344.10 ± 41.80 (n = 4) | |
Fenestration density (per μm GBM) | 3.10 ± 0.10 | 0.64 ± 0.30 | 1.28 ± 0.30 |
% SPS coverage | 55 ± 5 | ND | 41 ± 10 |
Foot process width (nm) | 400 ± 40 | ND | 460 ± 70 |
GBM thickness under SPS (nm) | 248 ± 10 | ND | 252 ± 9 |
GBM thickness uncovered | 196 ± 6 | ND | 240 ± 14a |
ND, not done; uPCR, urinary protein-creatinine ratio.
aP < 0.05.