Skip to main content
. 2010 Sep;21(9):1498–1509. doi: 10.1681/ASN.2009060617

Table 1.

Transgenic parameters characterized

Parameter WT Littermate Controls Heterozygous Animals Homozygous Animals
Glomerular volume (μl) 0.98 ± 0.16 (n = 8) 0.73 ± 0.07 (n = 18) 1.56 ± 0.11 (n = 36)
LpA 1.93 ± 0.32 (n = 8) 1.00 ± 0.12 (n = 18) 1.06 ± 0.16 (n = 23)
LpA/Vi 1.95 ± 0.17 (n = 8) 1.44 ± 0.11 (n = 18) 0.67 ± 0.07 (n = 23)
uPCR (mg/mmol) 20.16 ± 2.55 (n = 8) 20.74 ± 2.80 (n = 10) 14.80 ± 2.78 (n = 3)
Plasma creatinine (μmol/L) 3.40 ± 1.21 (n = 5) 4.50 ± 1.20 (n = 6) 6.00 ± 1.53 (n = 3)
Plasma urea (mmol/L) 8.60 ± 0.10 (n = 5) 9.32 ± 0.50 (n = 6) 11.07 ± 0.90 (n = 3)
GFR (μl/min) 306.70 ± 57.50 (n = 4) 344.10 ± 41.80 (n = 4)
Fenestration density (per μm GBM) 3.10 ± 0.10 0.64 ± 0.30 1.28 ± 0.30
% SPS coverage 55 ± 5 ND 41 ± 10
Foot process width (nm) 400 ± 40 ND 460 ± 70
GBM thickness under SPS (nm) 248 ± 10 ND 252 ± 9
GBM thickness uncovered 196 ± 6 ND 240 ± 14a

ND, not done; uPCR, urinary protein-creatinine ratio.

aP < 0.05.

HHS Vulnerability Disclosure