Table 4.
Intradialytic symptomatic hypotension, BP values, and antihypertensive therapy by phase and treatment groups
| Parameter | Treatment |
P | |||||
|---|---|---|---|---|---|---|---|
| Run-in Phase |
Evaluation Phase |
||||||
| HD | HF | HDF | HD | HF | HDF | ||
| No. of patients | 66 | 31 | 39 | 66 | 31 | 39 | |
| No. of sessions | 2096 | 1203 | 1249 | 11942 | 6502 | 5958 | |
| Sessions with symptomatic hypotension (n [%]) | 148 (7.1) | 118 (9.8) | 132 (10.6) | 939 (7.9) | 523 (8.0) | 309 (5.2) | |
| Symptomatic hypotension variation (%) | +0.8 | −1.8 | −5.4 | <0.001 | |||
| SBP (mmHg; mean ± SD) | 140.5 ± 17.6 | 139.9 ± 18.0 | 137.3 ± 18.9 | 140.5 ± 15.5 | 137.3 ± 18.6 | 141.5 ± 18.8 | |
| mean difference by phase (mmHg) | −0.0 | −2.6 | +4.2 | 0.038 | |||
| DBP (mmHg; mean ± SD) | 76.7 ± 10.2 | 75.8 ± 9.8 | 74.5 ± 12.6 | 75.4 ± 9.3 | 72.6 ± 9.4 | 74.7 ± 11.4 | |
| mean difference by phase (mmHg) | −1.3 | −3.2 | +0.2 | 0.096 | |||
| Heart rate (bits/min; mean ± SD) | 74.5 ± 8.2 | 72.7 ± 6.8 | 74.3 ± 10.4 | 73.9 ± 9.2 | 73.4 ± 6.9 | 75.4 ± 9.0 | |
| mean difference by phase (bits/m) | −0.6 | +0.7 | +0.9 | 0.250 | |||
| No. of antihypertensive drugs (median [IQR]) | 1.0 (0.0 to 2.0) | 1.0 (0.0 to 2.5) | 1.0 (0.7 to 2.0) | 1.0 (0.0 to 1.8) | 0.9 (0.0 to 2.0) | 1.0 (0.6 to 2.0) | 0.385 |
| Patients treated with antihypertensive drugs (%) | 48.6 | 58.3 | 75.0 | 56.1 | 62.1 | 75.9 | |
| difference by phase (%) | +7.5 | +3.8 | +0.9 | 0.676 | |||
| Postdialysis body weight (kg; mean ± SD) | 64.9 ± 9.7 | 60.7 ± 10.1 | 65.8 ± 12.9 | 64.8 ± 10.0 | 60.2 ± 10.3 | 65.2 ± 12.9 | |
| mean difference by phase (kg) | −0.1 | −0.5 | −0.6 | 0.508 | |||
| Net UF (L/session; mean ± SD) | 2.7 ± 0.7 | 2.4 ± 0.7 | 2.9 ± 0.7 | 2.7 ± 0.7 | 2.4 ± 0.7 | 2.9 ± 0.9 | |
| mean difference by phase (L/session) | −0.0 | −0.0 | −0.0 | 0.893 | |||
| Predialysis sodemia (mEq/L; mean ± SD) | 138.3 ± 3.3 | 138.9 ± 2.9 | 137.3 ± 3.2 | 138.0 ± 3.2 | 138.8 ± 2.8 | 137.3 ± 2.9 | |
| mean difference by phase (mEq/L) | −0.3 | −0.1 | −0.0 | 0.942 | |||
| Postdialysis sodemia (mEq/L; mean ± SD) | 139.0 ± 3.4 | 139.7 ± 3.0 | 138.7 ± 3.4 | 138.7 ± 3.2 | 139.1 ± 2.6 | 138.8 ± 2.7 | |
| mean difference by phase (mEq/L) | −0.3 | −0.6 | −0.1 | 0.808 | |||
| ΔSession sodemia (mEq/L; mean ± SD) | 0.7 ± 3.3 | 0.8 ± 2.6 | 1.4 ± 2.8 | 0.7 ± 2.6 | 0.3 ± 1.7 | 1.5 ± 2.1 | |
| mean difference by phase (mEq/L) | −0.0 | −0.5 | −0.1 | 0.848 | |||
Components of sodium balance (body weight, net UF, pre/postsodiemia values, and Δpost/presession sodiemia values) were also shown. Intradialytic symptomatic hypotension ameliorated in pre-HF (P = 0.011) and in pre-HDF (P < 0.001) groups compared with the HD group, but predialysis SBP values rose in the pre-HDF group as compared with the other groups (P = 0.038).