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. 2010 Oct;21(10):1732–1744. doi: 10.1681/ASN.2010020143

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Copyright © 2010 by the American Society of Nephrology

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Figure 5. — UUO activates redundant inflammatory pathways in mouse kidneys. (A) Nlrp1b and Nlrp12 mRNA expression (quantitative real time reverse transcriptase–PCR, normalized to GAPDH) in ligated (Lig) or contralateral (Ctrl) Nlrp3^+/+ mouse kidneys at 14 days after UUO. (B) Hyaluronan content (ELISA) in kidney lysates from Nlrp3^+/+ and Nlrp3^−/− mice at 14 days after UUO (sham versus Nlrp3^+/+, P < 0.01, versus Nlrp3^−/−, P < 0.05; Nlrp3^+/+ versus Nlrp3^−/−, NS; n = 5) (C) Immunoblotting for biglycan and HMGB1 in kidney lysates from Nlrp3^+/+ and Nlrp3^−/− mice at 3, 7, and 14 days after UUO. Fourteen-day sham and contralateral kidneys are used as controls.