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. 2010 Oct;21(10):1732–1744. doi: 10.1681/ASN.2010020143

Figure 6.

Figure 6.

Renal fibrosis is reduced in Nlrp3−/− mice after UUO. (A) Masson trichrome staining on Nlrp3+/+ and Nlrp3−/− kidneys at 14 days after UUO. (B) Quantification of renal fibrosis area at 14 days (mean ± SD area; P < 0.01, Nlrp3+/+ versus Nlrp3−/−; n = 6 Nlrp3+/+ and 10 Nlrp3−/−). (C) E-cadherin and α-smooth muscle actin (αSMA) expression in Nlrp3+/+ and Nlrp3−/− kidneys at 14 days after UUO (immunoblotting). Fourteen-day sham and contralateral (Ctrl) kidneys are used as controls. (D) Quantification of E-cadherin and αSMA expression in Nlrp3+/+ and Nlrp3−/− mice at 14 days normalized to β-tubulin (mean ± SD; P < 0.05, Nlrp3+/+ versus Nlrp3−/−; n = 6 to 10).